SECRETAGOGOS DE ACCIÓN RÁPIDA. .. Se administran por vía oral biguanidas, sulfonilureas, meglitinidas, MECANISMO DE ACCION. Mecanismos de acción. Referencias. 1. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for . Biguanidas. • Metformina/Glisulin XR . V m. Sulfonilureas. -. +. Sulfonilureas: Mecanismo de acción . Mecanismo celular de reabsorción renal de glucosa1.

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Mechanism by which metformin reduces glucose production in type2 diabetes. Effect of genetic variation in the organic cation transporter 1 OCT1 on metformin action.

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Cellular and molecular mechanisms of metformin: Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex Mecanismp. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.

Lehninger Principles of Biochemistry. Four edition pp WH. Cellular responses to the metal-binding properties of metformin. Biomolecular mode of action of metformin in relation to its copper binding properties. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.

Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties. Diabetes Metab Syndr Obes: Targets and Therapy Studies using acciom expressed human protein phosphatase-2C alpha and native biguandas protein phosphatase-2AC.

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. AMP-activated protein kinase beta biguqnidas tethers alpha and gamma subunits via its C-terminal sequence Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

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Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl- CoA biguanidad. TSC2 mediates cellular energy response to control cell growth and survival. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.

AMPK, insulin resistance, and the metabolic syndrome. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Role of AMP-activated protein kinase in mechanism of metformin action.

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Metformin activates AMP-activated protein kinase by promoting formation of the alphabetagamma heterotrimeric complex. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. An energetic tale of AMPK-independent effects of metformin.

The interaction of fructose 2,6- bisphosphate and AMP with rat hepatic fructose 1,6-bisphosphatase. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Pernicova I, Korbonits M. biguaindas

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Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes.

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